32 articles - From Friday Apr 07 2023 to Friday Apr 14 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Am J Clin Nutr |
Prevalence and clinical implications of abnormal body composition phenotypes in patients with COVID-19: a systematic review. Abnormalities in BC were prevalent in patients with COVID-19. Although conflicting associations were observed among certain BC abnormalities and clinical outcomes, higher muscle echo intensity (reflective of myosteatosis) and lower PhA were more consistently associated with greater mortality risk. Likewise, high IMAT and VAT were associated with mortality and ICU admission, respectively. |
| Inflamm Bowel Dis |
Prevalence of Extraintestinal Manifestations in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. To our knowledge, this is the first meta-analysis that reports on the prevalence of at least 1 joint, ocular, or skin extraintestinal manifestation in IBD. Our results are largely consistent with figures and statements quoted in the literature. However, our findings are based on significantly larger cohort sizes. Thus, our results have the potential to better power studies and more accurately counsel patients. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
A Longitudinal Observational Study of Skeletal Development Between Ages 3 Months and 6 Years in Children Fed Human Milk, Milk Formula or Soy Formula. Together, these data suggest that while SF infants at age 6 months may have some enhanced bone metabolism compared to BF and MF infants, as indicated by the urinary biomarkers, no differences in bone metabolism or BMD were noted between ages 2 and 6 years. Clinical trial registry number NCT00616395; |
Associations of dietary isothiocyanate exposure from cruciferous vegetable consumption with recurrence and progression of non-muscle invasive bladder cancer: Findings from The Be-Well Study. Our findings indicate the possible beneficial role of dietary ITCs in NMIBC prognosis. Given the compelling preclinical evidence, increasing dietary ITC exposure with CV intake could be a promising strategy to attenuate recurrence and progression risks in patients with NMIBC. |
Development and validation of new predictive equations for resting metabolic rate (RMR) of older adults, aged 65 years and over. The new equations, using simple measures of weight, height and age, improve accuracy in prediction of RMR in populations in clinical practice. However, no equation performs optimally at the individual level. |
Habitual intake of dietary dicarbonyls is associated with greater insulin sensitivity and lower prevalence of type 2 diabetes: The Maastricht Study. Higher habitual consumption of the dicarbonyls MGO and 3-DG was associated with better insulin sensitivity and with lower prevalence of type 2 diabetes, after excluding individuals with known diabetes. These novel observations warrant further exploration in prospective cohorts and intervention studies. |
Supplementation with a beta-glucan tablet has no effect on hyperlipidemia: a randomized, placebo-controlled clinical trial. In subjects with LDL-C above 3.37 mmol/L, a tablet formulation of ß-glucan was not effective in reducing LDL-C concentration or other lipid sub-fractions when compared to placebo. Clinicaltrials Gov identifier NCT03857256. |
The relationship of omega-3 fatty acids with dementia and cognitive decline: evidence from perspective cohort studies of supplementation, dietary intake, and blood markers. Dietary intake or long-term supplementation of omega-3 fatty acid may help reduce the risk of AD or cognitive decline. |
Validation of the smartphone-based dietary assessment tool 'Traqq' for assessing actual dietary intake by repeated 2-hour recalls in adults: comparison with 24h recalls and urinary biomarkers. Comparing 2hR-days with 24hRs showed relatively similar group-level bias for energy, most nutrients, and food groups. Differences were mostly due to higher intake estimates by 2hR-days. Biomarker comparisons showed less underestimation by 2hR-days as compared to 24hRs, suggesting that 2hR-days are a valid approach to assess intake of energy, nutrients and food groups. |
| Inflamm Bowel Dis |
Development and Validation of Claims-Based Definitions to Identify Incident and Prevalent Inflammatory Bowel Disease in Administrative Healthcare Databases. Through a combination of diagnosis, procedural, and medication codes in insurance claims data, we were able to identify incident and prevalent IBD cases with high accuracy. These algorithms can be useful for the ascertainment of IBD cases in future studies. |
Dual Biologic or Small Molecule Therapy in Refractory Pediatric Inflammatory Bowel Disease (DOUBLE-PIBD): A Multicenter Study from the Pediatric IBD Porto Group of ESPGHAN. Dual biologic therapy may be effective in children with refractory IBD. The potential efficacy should be weighed against the risk of serious adverse events. |
In-Depth Assessment of Endoscopic Remission in Inflammatory Bowel Disease Treated by Anti-TNF or Vedolizumab. Despite endoscopic, biological, and even histological remission, we found a high prevalence of endomicroscopic abnormalities, which were not different between anti-tumor necrosis factor- and vedolizumab-treated patients. The clinical significance of these anomalies remains to be clarified. |
The Safety of Dilation of Ileoanal Strictures With Mechanical or Balloon Dilation Is Similar Among Patients After Ileal Pouch-Anal Anastomosis. Among patients with ileoanal and rectal strictures, mechanical and balloon approaches to dilation demonstrated similar safety profiles and effectiveness. Mechanical dilation with Hegar dilators appears to be an effective and safe approach to the treatment of distal strictures after IPAA. |
| J Crohns Colitis |
"Correlation of ultrasound scores with endoscopic activity in Crohn's disease: a prospective exploratory study". All IUS scores provided solid correlation with endoscopy and clinical symptoms. IBUS-SAS outperformed the others due to a more granular description that might particularly help in stratifying different levels of disease activity. Therefore, the use of IBUS-SAS in Centres with well-founded expertise in IUS may be suggested. |
Community Types Of The Human Gut Virome Are Associated With Endoscopic Outcome In Ulcerative Colitis. This study proposed two gut virome configurations that may be involved in the pathophysiology of IBD. Interestingly, those viral configurations are further associated with therapeutic success, suggesting a potential clinical relevance. |
| Liver Transpl |
Development and validation of a REcurrent Liver cAncer Prediction ScorE (RELAPSE) following liver transplantation in patients with hepatocellular carcinoma: analysis of the us multicenter hcc transplant consortium. We develop and externally validate a RELAPSE score which accurately discriminates post-LT HCC recurrence risk, and may allow for individualized post-LT surveillance, immunosuppression modification, and selection of high-risk patients for adjuvant therapies. |
Development of a portable abdominal normothermic regional perfusion (A-NRP) program in the United States. The current report describes the feasibility of a portable A-NRP program that can be utilized in the United States. Excellent short-term post-transplant results were achieved with both livers and kidneys procured from A-NRP. |
Ethnic disparities in waitlist outcomes of non-alcoholic steatohepatitis patients listed for liver transplantation in the United States. There are significant racial and ethnic disparities in waitlist outcomes of NASH patients in the United States. Hispanic patients are less likely to receive LT and more likely to die while on the waitlist compared to non-Hispanic Whites despite being listed with lower MELD scores. |
From large-for-size to large-for-flow: a paradigm shift in liver transplantation. Low portal flow is a significant predictor of post-LT morbi-mortality, independently of LFS when defined as a morphological metric alone. Consequently, we propose the novel concept of large-for-flow which may guide graft selection and improve perioperative management of LPF. |
Improved recurrence-free survival in hepatocellular carcinoma patients with post-transplant plasma exchange. Post-transplant TPE was found to improve recurrence-free survival after ABO-incompatible living donor liver transplantation for HCC, particularly in advanced cases with microvascular invasion and beyond Milan criteria. These findings suggest that TPE may have a potential role in improving oncological outcomes in HCC patients undergoing liver transplantation. |
| Pancreatology |
Association of palliative care management and survival after chemotherapy discontinuation in patients with advanced pancreatic adenocarcinoma: A retrospective single-centre observational study. The study suggests that PC may be associated with longer survival after CD in advanced PA patients. However, PC is underused, and patients are referred late in their care pathway. |
Preclinical safety evaluation of calcineurin inhibitors delivered through an intraductal route to prevent post-ERCP pancreatitis demonstrates endocrine and systemic safety. Intraductal delivery of RC-CnI formulation was safe and well-tolerated with no significant acute or subacute endocrine or systemic toxicities, underscoring its clinical utility to prevent PEP. |
Plenty of the editorials are available as full text through the publisher website using the provided link
misc publications eg case reports, tools of the trade, images of the month, etc…
| Inflamm Bowel Dis |
| Liver Transpl |
Letters to the editors and authors’ replies